Monocarboxylic acid esters of propoxylated fatty alcohols as pigment dispersants

ABSTRACT

A novel fatty polypropoxylate ester which is an ester of an aliphatic or an aromatic monoacid formed by reacting the acid with a stoichiometric excess of a polypropoxylated fatty alcohol. The compounds have the following structural formula:  
                 
 
     wherein R 1  is a polypropoxylated fatty alcohol having the structural formula:  
                 
 
     wherein R 5  is a saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic moiety containing from 4 to 24 carbon atoms, and x is an integer from 3 to 30; and  
     wherein R has the structural formula:  
     a)  
                 
 
     wherein R 2 , R 3  and R 4  are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl; or  
     b)  
                 
 
     wherein R 6  is H or OH or NH 2  or methyl or ethyl.  
     The compounds possess exceptional pigment dispersant and esthetic emollient properties for use in personal care and topical pharmaceutical preparations, e.g., lipsticks, cream foundations, waterproof sunscreens, sunscreen lotions.

RELATED APPLICATIONS

[0001] This application claims the benefit of provisional application U.S. patent application Ser. No. 60/273,073 filed Mar. 02, 2001. The entire disclosure of this application is incorporated herein by reference.

BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to fatty polypropoxylate esters of aliphatic and aromatic monocarboxylic fatty acids. These compounds have unique pigment dispersion and emolliency properties. The fatty polypropoxylate esters of the present invention are particularly useful in the formulation of sunscreen lotions, sunscreen sprays, self-tanning compositions, make-ups and other pigmented products, cold creams, lotions, skin moisturizers, antiperspirants, after shaves, pre-electric shaves, topical pharmaceutical products, lipsticks and cleansing creams. The present invention further relates to topical preparations incorporating the fatty polypropoxylate esters of the present invention.

[0004] 2. Prior Art

[0005] There has been an increased awareness among the public of the potential for skin damage from ultraviolet radiation, with frequent news reports of greater risk from sun-induced photo aging, melanoma, and other skin disorders. The contribution of UVA radiation as well as the widely recognized contribution of UVB radiation to skin damage has engendered the development of a broad range of sunscreen products from the cosmetic industry. Sophisticated sunscreen formulations have been developed which incorporate combinations of UVA and UVB absorbers in vehicles which provide wash-off resistance and enhanced esthetics. Because of the regulatory limitations on the levels at which organic sunscreens may be used in formulations and the desirability for high absorbency formulations (high SPF) with broad spectrum protection, the use of physical sunscreens in conjunction with organic sunscreens in formulations has increased greatly.

[0006] Physical sunscreens consist of very finely divided (micronized) inorganic metallic oxides, typically Titanium Dioxide or Zinc Oxide. These micronized physical sunscreens appear transparent on the skin by virtue of their small particle size. Similar to other finely divided particulate products used in cosmetic formulations such as pigments for foundations and makeups, micronized Zinc Oxide and micronized Titanium Dioxide are dispersed within the formulation by mixing, using either low-shear or high-shear methods. In order to make stable, cosmetically acceptable products, uniform dispersions must be produced, with all particles wetted out and which remain in suspension over a period of time without settling, gelling or agglomerating. Producing such stable suspensions has proved to be a challenge, although some successes have been achieved.

[0007] For example, U.S. Pat. No. 5,116,604 to Fogel describes the use of neopentanoate esters, in particular isoarachidyl neopentanoate, as cosmetic emollients for sunscreen products. U.S. Pat. No. 5,716,602 to Uick describes sunscreens formulated to include a water resistance agent and an insect repellent. One form has in an aqueous emulsion DEET, a sunscreen agent, an anionic surfactant, an alkylated PVP, and octyldodecyl neopentanoate. Both of these inventions use of Elefac I-205, i.e., Octyldodecyl Neopentanoate.

[0008] U.S. Pat. No. 5,476,643 to Fogel describes the use of two specific neopentyl glycol diesters, as wetting, dispersing, spreading and deterging agents for micronized TiO₂, ZnO and other pigments. These esters, neopentyl glycol di-2-ethyl hexanoate and neopentyl glycol di-isostearate, are used in varying combinations and may also be used with an emulsifying agent for a water dispersible pigmented make-up cleaner composition.

[0009] Emollients such as Finsolv TN (C₁₂-C₁₅ Alkyl Benzoate) and TRIVENT NP-13 (Tridecyl Neopentanoate) have also been employed with some success as dispersants for physical sunscreens, as have various glycols and propoxylates, such as PPG-3 Myristyl Ether. See for example, U.S. Pat. No. 5,928,631 to Lucas which describes a skin composition for controlling environmental malodors on the body. The composition comprises from about 0.1% to about 5%, by weight of a solubilized, water-soluble, uncomplexed cyclodextrin; from about 0.1% to about 36%, by weight of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; one or more surfactants, and an aqueous carrier.

[0010] Still, there remains a need for superior dispersants with desirable esthetic properties for use in pigmented cosmetic compositions, particularly sunscreen formulations that contain physical sunscreens.

[0011] Additionally, since formulators often find it useful to fully disperse pigments, e.g., micronized metallic oxides, in a portion of the oil phase by high shear techniques such as milling, there is a need for forming oil phase dispersions which have a high solids content of pigments, particularly micronized metallic oxides, that are fluid.

OBJECTS AND SUMMARY OF THE INVENTION

[0012] It is a broad object of the present invention to provide a class of agents with superior dispersant properties suitable for use in the formulation of topical personal care products.

[0013] It is another object of this invention to provide compounds which are superior dispersants and have desirable esthetic properties for use in pigmented cosmetic compositions.

[0014] It is a further object of this invention to provide compounds which are superior dispersants, and have desirable esthetic properties for use in sunscreen formulations containing physical sunscreens.

[0015] It is yet another object of this invention to provide a dispersant that is useful for formulating by high shear techniques, such as milling, oil phase dispersions that have a high solids content of pigments and micronized metallic oxides.

[0016] It is a more specific object of this invention to provide dispersing agents having improved dispersant properties that are polypropoxylated fatty alcohol chains covalently bonded by ester linkages to aliphatic and aromatic monocarboxylic acids.

[0017] The aforedescribed objects and others are achieved through the present invention. Broadly, the invention is directed to certain aliphatic and aromatic monocarboxylic acid esters of polypropoxylated fatty alcohols. These compounds demonstrate unusual and unexpectedly superior properties as pigment dispersants, especially for micronized Zinc Oxide, e.g., Z-Cote HP-1 from BASF, micronized Titanium Dioxide, and uncoated pigments such as those used in foundations and makeup products. Additionally, these propoxylated alcohol esters can be used to produce uniform milled dispersions of pigments and micronized metallic oxide sunscreens that have exceptionally high solids content, exhibit unusual fluidity and when applied to the skin demonstrate a dry, elegant emolliency.

[0018] Generally, the fatty polypropoxylate esters of this invention are esters of an aliphatic or an aromatic monoacid formed by reacting an acid with a stoichiometric excess of a polypropoxylated fatty alcohol.

[0019] Broadly, the compounds of this invention have the following structural formula:

[0020] wherein R₁ is derived from a polypropoxylated fatty alcohol and has the structural formula:

[0021] wherein R₁ is a saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic moiety containing from 4 to 24 carbon atoms, and x is an integer from 3 to 30; and

[0022] wherein R is derived from an aliphatic or aromatic monocarboxylic acid and has the structural formula:

[0023] a)

[0024] wherein R₂, R₃ and R₄ are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl; or

[0025] b)

[0026] wherein R₆ is H or OH or NH₂ or methyl or ethyl.

[0027] The present invention provides fatty polypropoxylate esters possessing exceptional pigment dispersant and esthetic emollient properties long sought by formulators for use in personal care and topical pharmaceutical preparations.

[0028] In accordance with another aspect of the present invention, there are provided compositions for topical application that include such the fatty polypropoxylate esters.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0029] The emollient dispersants of the present invention are fatty polypropoxylate esters of aliphatic and aromatic monocarboxylic acids.

[0030] The aliphatic monocarboxylic acids suitable for preparing the compounds of the present invention contain from 2 to 24 carbon atoms. The aromatic monocarboxylic acids suitable for preparing the compounds of the present invention contain from 7 to 9 carbon atoms. Preferred aliphatic monocarboxylic acids contain from 4 to 18 carbon atoms. Examples of suitable aliphatic monocarboxylic acids include 2-Ethyl Hexanoic acid, Caproic acid, Neopentanoic acid, Isostearic acid, Neoheptanoic acid and Oleic acid. Examples of suitable aromatic moncarboxylic acids include Benzoic acid and p-Aminobenzoic acid.

[0031] The fatty polypropoxylate esters of the present invention are formed by reacting the above described aliphatic and aromatic monocarboxylic acids with polypropoxylated fatty alcohols. The polypropoxylated fatty alcohols preferably have between 3 and 30 moles of propoxylation, and most preferably between 3 and 10 moles of propoxylation. The fatty alcohols utilized to prepare these polypropoxylated fatty alcohols may be saturated or unsaturated, substituted or unsubstituted, aliphatic or aromatic, and may be straight chained or branched chained, having between 6 and 24 carbon atoms. Saturated aliphatic fatty alcohols, either straight chain or branched chain, with 12 to 14 carbon atoms are most preferred.

[0032] The fatty polypropoxylated esters of the present invention are particularly useful as agents that confer superior pigment dispersion and unusual, dry, elegant emollient properties to topical formulations, especially to those containing physical sunscreens and other pigments. The fatty polypropoxylated esters of the present invention are also singularly useful in the preparation of fluid, high solids content dispersion grinds of micronized physical sunscreens such as Zinc Oxide and Titanium Dioxide for use in sunscreen formulations. The esters are useful in the formulation of sunscreen lotions, sunscreen sprays, self-tanning compositions, make-ups and other pigmented products, cold creams, skin moisturizers, antiperspirants, after shaves, pre-electric shaves, topical pharmaceutical products, lipsticks and cleansing creams. The dry, elegant emolliency imparted by the fatty polypropoxylated esters of the present invention is manifested primarily when the esters are utilized as a full or partial replacement for the mineral oil and petrolatum emollient agents of the prior art. A distinct improvement in the esthetics and emollient properties of mineral oil and petrolatum-based products is discernible when as little as 25% of the mineral oil or petrolatum has been replaced by the fatty polypropoxylated esters of the present invention. Therefore, topical preparations in accordance with the present invention can include a second emollient agent of mineral oil, petrolatum and the like along with the fatty polypropoxylated esters of the present invention in a ratio of up to about 3:1 of the second emollient agent to the emollient agent of the present invention. These topical formulations include the essential compounds of the present invention, one or more active ingredients and water. As mentioned above, a second emollient agent of mineral oil, petrolatum and the like may be included as desired. Suitable active ingredients for use in topical preparations include organic sunscreens, physical sunscreens, self-tanning agents, pigments, opacifying agents, moisturizers, film-formers, thickening agents, emulsifiers, antiseptic agents, conditioning agents and deodorant actives.

[0033] The topical preparations of the present invention, in addition to including the primary components of the fatty polypropoxylated esters of the present invention, one or more active ingredients, water and the optional second emollient agent, may also include fragrances, humectants, protein derivatives, coloring agents, preservatives and the like.

[0034] Typical topical formulations in accordance with the present invention include the essential fatty polypropoxylated esters of the present invention either alone or in combination with the second emollient agent, in a range of from about 0.2% to about 40.0% by weight of the composition, preferably from about 2.0% to about 20.0% of the composition. As noted above, the second emollient agent, when present, may be blended with the fatty polypropoxylate ester emollients of the present invention in a ratio of about 3:1 of the former to the latter.

[0035] The topical preparations of the present invention are formulated using techniques that are well known to practitioners in the cosmetic formulating art. Typically, the ingredients are combined with mixing and the application of heat as necessary until a homogeneous product is obtained. The water soluble ingredients and water-insoluble ingredients are mixed together separately and combined with suitable emulsifying agents.

[0036] The topical compositions of the present invention are topically applied directly to the skin. The compositions can be delivered by placing the composition into a dispensing means and applying an effective amount via spraying or rubbing the composition onto the desired skin surface, either the entire body or selected portions thereof. Preferably the dispensing means is a wipe or a spray dispenser. Distribution of the composition of the present invention can also be achieved by using a pre-formed applicator such as a roller, pad, sponge, tissue, cotton ball, hand, etc. Alternatively, the user may combine the composition of the present invention with a wipe substance of his or her own choosing. To do this, the user simply chooses a wipe substance such as a commercial paper towel, tissue, sponge, cotton, pad, washcloth, or the like; and pours, from a bottle or other suitable container, a solution of the composition of the present invention over the chosen wipe substance and applies the composition to the desired area of the body. In this manner, the user may use as much or as little of the composition of the present invention as he/she desires, depending upon their intended use.

[0037] The following examples set forth below are intended to illustrate certain aspects of the present invention, and are not to be considered limiting as to the scope and nature of the present invention.

EXAMPLES

[0038] Preparation of Compounds

[0039] The fatty alcohols, e.g., Myristyl alcohol, were reacted with Propylene Oxide in the presence of alkaline catalysts in the conventional fashion, followed by neutralization with a suitable acid such as Phosphoric Acid. The resultant polypropoxylated fatty alcohol was reacted in the conventional fashion with a stoichiometric amount of the aliphatic or aromatic fatty acid, e.g., Ethylhexanoic acid, followed by neutralization with a suitable base such as Sodium Carbonate. The typical reaction is as follows:

[0040] Preparation of PPG-3 Myristyl Ether Neoheptanoate

[0041] 3 moles (642 grams) of Myristyl Alcohol were charged to an autoclave, and 0.1% of Potassium Hydroxide was added as a catalyst. The autoclave was purged with Nitrogen and 9 moles (522 grams) of Propylene oxide were added at a temperature of 150-160° C. and a pressure of 30-40 psi. At the completion of the addition reaction, the batch was cooled to 80° C and neutralized with Phosphoric Acid. The resultant 1,164 grams of product, PPG-3 Myristyl Ether, a pale yellow liquid, was charged to a four-neck flask. 3 moles (390 grams) of Neoheptanoic Acid were charged to the flask, along with a catalytic amount of methanesulfonic acid. The reaction mixture was heated with agitation to 190° C. until an acid value of less than 8 mg KOH was obtained. The reaction mixture was cooled to 80° C., washed with a dilute Sodium Carbonate solution sufficient to neutralize the residual acid present, followed by washing with water. The ester layer was separated and heated under vacuum until a moisture content of less than 0.3% was obtained, followed by vacuum filtration. The resultant product, PPG-3 Myristyl Ether Neopentanoate, was a clear pale yellow liquid having an acid value of 0.12 mg KOH.

[0042] Preparation of PPG-4 Butyloctyl Ether Ethylhexanoate

[0043] 4 moles (744 grams) of Butyloctanol were charged to an autoclave, and 0.1% of Potassium Hydroxide was added as catalyst. The autoclave was purged with Nitrogen and 16 moles (928 grams) of Propylene Oxide were added at a temperature of 150-160° C. and a pressure of 30-40 psi. Upon completion, the batch was cooled to 80° C. and neutralized with Phosphoric Acid. The resultant product, PPG-4 Butyloctyl Ether, was a very pale yellow liquid. A four-neck flask was charged with 1,224 grams of the PPG-4 Butyloctyl Ether, along with 3 moles (432 grams) of 2-Ethyl Hexanoic Acid. A catalytic amount of p-Toluenesulfonic Acid was added and the reaction mixture was heated with agitation to 160° C. until an acid value of less than 5 mg KOH was obtained. The reaction mixture was cooled to 80° C., washed with a dilute Sodium Hydroxide solution sufficient to neutralize the residual acid present, followed by washing with water. The ester layer was separated and heated under vacuum until a moisture content of less than 0.2% was obtained, followed by vacuum filtration. The resultant product, PPG-4 Butyloctyl Ether Ethylhexanoate, was a clear very pale yellow liquid having an acid value of less than 0.1 mg KOH.

[0044] Dispersion Efficacy Testing

[0045] By use of a simple screening test for dispersant effectiveness, we have discovered that these aliphatic and aromatic esters of polypropoxylated fatty alcohols demonstrate greatly superior pigment wetting properties and greatly enhanced ability to keep physical sunscreen ingredients such as micronized Zinc Oxide in suspension. The tests show that these aliphatic and aromatic monocarboxylic acid esters of polypropoxylated fatty alcohols are superior to commonly used dispersants such as C12-C15 Alkyl Benzoate, Octyldodecyl Neopentanoate, Neopentyl Glycol Dietylhexanoate, and Tridecyl Neopentanoate, Propylene Glycol, and PPG-3 Myristyl Ether.

[0046] A dispersion of 20 grams of micronized Zinc Oxide (Z-COTE HP-1) and 80 grams of the dispersant to be tested was prepared by adding the Zinc Oxide to the test dispersant under low shear propeller agitation and mixing for 15 minutes. A 10 ml aliquot of the dispersion was then centrifuged for 10 minutes at 3500 rpm in a graduated conical centrifuge tube, and the degree of separation was noted. Using this test, dispersions were made with two of the test compounds, PPG-3 Myristyl Ether Neoheptanoate and PPG-3 Butyloctyl Ether Ethylhexanoate. These tests showed essentially no evidence of separation after centrifugation. By comparison, dispersions made with C₁₂-C₁₅ Alkyl Benzoate, Octyldodecyl Neopentanoate and Neopentyl Glycol Dietylhexanoate demonstrated approximately 30-35% separation after centrifugation, while a dispersion made with Tridecyl Neopentanoate showed an approximate 25% separation. Dispersions made with Propylene Glycol and PPG-3 Myristyl Ether demonstrated separations in excess of 50% upon centrifugation.

[0047] In other tests, 50 percent milled dispersions of micronized Titanium Dioxide (WC&D CTFA 328) were prepared in PPG-3 Myristyl Ether Neoheptanoate and in Elefac I-205 by first mixing the pigment with the vehicle until the pigment was thoroughly wetted, and then passing the resultant mixture over a three roller mill. The quality of the grind was measured using a Hegman Gauge, confirming a particle size of less than one micron for each preparation. The grind prepared using Elefac I-205 was an immobile paste, while the grind prepared using PPG-3 Myristyl Ether Neoheptanoate was a thin fluid. Using the same methodology, 50 percent milled dispersions of Ultrafine Zinc Oxide (Z-Cote, untreated) were prepared in PPG-3 Myristyl Ether Neoheptanoate and in Finsolv TN. The grind prepared using Finsolv TN was an immobile paste, while the grind prepared using PPG-3 Myristyl Ether Neoheptanoate was a thin fluid.

[0048] Cosmetic Preparations

[0049] The following examples, while not intended to be limiting, demonstrate topical preparations formulated into a lipstick, a sunscreen lotion containing micronized Titanium Dioxide, a waterproof sunscreen lotion containing micronized Zinc Oxide, and a pigmented cream foundation.

[0050] Preparation of Emollient Lipstick Phase INCI Name Percent A PPG-3 Myristyl Ether Neoheptanoate (TRIVASPERSE NH - Trivent) 10.00 Castor Oil 41.35 B Red #6 (1:2 in Castor Oil) 1.90 Red #7 (1:1 in Castor Oil) 2.38 Yellow #5 (1:2 in Castor Oil) 0.32 Titanium Dioxide (1:1 in Castor Oil) 1.75 Blue #1 (0.75:2.25 in Castor Oil) 0.10 C Mango Butter (Trivent) 7.00 Octyl Methoxycinnamate (Trivent OMC - Trivent) 2.50 Hydrogenated Polyisobutene (Panalane H-300 E - Lipo) 5.00 Candelilla Wax 4.50 White Beeswax 4.50 Ozokerite Wax 5.00 Camauba Wax 1.50 Emulsifying Wax 0.75 Polyglyceryl-3 Methylglucose Distearate (Tego Care 450 - Goldschmidt) 2.50 D Nylon 12 And Boron Nitride (Liponyl 10 BN 6069 - Lipo) 8.00 E Tocopheryl Acetate 0.10 Wheat Germ Oil 0.25 Isopropylparaben, Isobutylparaben, Butylparaben 0.60 (Liquipar Oil-Sutton Labs) Total 100.00

[0051] Disperse B into A. Heat C to 80°-85° C. and mix until melted and uniform. Heat AB to 80°-85° C. and add to C while mixing slowly. Maintain temperature and mix until uniform. Take care not to aerate batch. Mix and cool to 65° C. Add D and E. Maintain temperature, mix until uniform, then pour into molds.

[0052] Preparation of Cream Foundation Phase NCI Name Percent A Deionized Water 35.95 Triethanolamine, 99% 1.85 Glycerine, USP 3.00 Trisodium EDTA 0.10 Simethicone (Anti-Foam AF-Dow Corning) 0.10 B Glyceryl Stearate 3.50 Stearic Acid 3.00 Laureth-2 31.00 Cetyl Alcohol 3.00 Hydrogenated Vegetable Oil 7.50 C PPG-3 Myristyl Ether Neoheptanoate (TRIVASPERSE 5.00 NH - Trivent) Dimethicone 2.00 Iron Oxide Red 0.20 Iron Oxide Yellow 0.63 Iron Oxide Black 0.08 Iron Oxide Brown 0.09 Titanium Dioxide 1.00 Talc 1.00 D Carbomer (Carbopol 940, 2% aqueous solution - BF- 30.00 Goodrich) E Phenoxyethanol (and) Methylparaben (and) Butylparaben 1.00 (and) Ethylparaben (and) Propylparaben (Phenonip - Nipa) Total 100.00

[0053] In main vessel, mix and heat Phase A to 65-70° C. In a separate vessel, mix and heat Phase B to 65-70° C. In an appropriately-sized vessel, mix Phase C until completely dispersed. When Phase B is at temperature, add Phase C to Phase B and mix until uniform. Begin homogenizing Phase A. Slowly add combined Phase B to Phase A while homogenizing. Homogenize for 5-10 minutes, until uniform. Switch to propeller mixer and begin cooling batch. At 55-60° C., add Phase D to main batch. Maintain minimum temperature of 50° C. Cool batch with stirring to 35-40° C. and add Phase E. Mix until uniform. Continue mixing while cooling batch to room temperature (20-25° C.).

[0054] Preparation of Waterproof Sunscreen (Zinc Oxide) Phase INCI Name Percent A Polyglyceryl-4 Isostearate (and) Cetyl Dimethicone Copolyol 5.00 (and) Hexyl Laurate (Abil WB-09- Goldschmidt) Cetyl Dimethicone (Abil Wax 9801 - Goldschmidt) 1.00 Beeswax 0.75 Octyl Methoxycinnamate (Trivent OMC) 7.50 Octyl Palmitate (Trivent OP) 3.00 Cetyl Acetate (and) Acetylated Lanolin Alcohols (Trivent ALA) 2.00 Cyclopentasiloxane 3.00 Cetyl Palmitate (Trivent CP) 1.00 Dimethicone 0.25 B PPG-3 Myristyl Ether Neoheptanoate (TRIVASPERSE NH - Trivent) 7.50 Zinc Oxide (Z-Cote- BASF) 7.50 C Deionized Water 59.60 Sodium Chloride 0.80 Trisodium EDTA 0.10 D Phenoxyethanol (and) Methylparaben (and) Butylparaben (and) Ethylparaben (and) Propylparaben (Phenonip - Nipa) 1.00 Total 100.00

[0055] In main vessel, mix and heat Phase A to 70° C. In an appropriately-sized vessel, mix Phase B until completely dispersed. When Phase B is dispersed, add to Phase A. In a separate vessel, mix and heat Phase C to 70° C. At temperature, add Phase C to Phase A slowly with stirring. Homogenize batch for 5-10 minutes. Switch to propeller mixer and cool batch to 45° C. At 45° C., add Phase D to batch and mix until uniform. Continue mixing and cool batch to room temperature (20-25° C.).

[0056] Preparation of Sunscreen Lotion (Titanium Dioxide) Phase INCI Name Percent A Deionized Water 60.20 Trisodium EDTA 0.10 Butylene Glycol 2.00 Xanthan Gum 0.30 B Octyl Methoxycinnamate (Trivent OMC) 7.50 Glyceryl Stearate/PEG- 100 Stearate 1.50 Cetyl Dimethicone (Abil Wax 9801 - Goldschmidt) 1.00 Pentaerythritol Tetra-2-Ethylhexanoate (Trivent PE-48) 3.00 Cetearyl Alcohol 2.50 Ceteareth-20 0.40 Tocopheryl Acetate 0.50 Beeswax 0.50 Cetyl Palmitate (Trivent CP) 1.25 C PPG-3 Myristyl Ether Neoheptanoate (TRIVASPERSE 8.75 NH - Trivent) Titanium Dioxide (Micro LA-20 - Grant) 6.50 Polysorbate-20 1.00 D Polyacrylamide (and) C₁₃₋₁₄ Isoparaffm (and) Laureth- 72.00 (Sepigel 305 - Seppic) E Phenoxyethanol (and) Methylparaben (and) Butylparaben 1.00 (and) Ethylparaben (and) Propylparaben (Phenonip - Nipa) Total 100.00

[0057] In main vessel, mix and heat Phase A to 65-70° C. In a separate vessel, mix and heat Phase B to 65-70° C. In an appropriately-sized vessel, mix Phase C until completely dispersed. At temperature, add Phase B to Phase A and begin homogenization. While homogenizing, add Phase C to batch. Continue homogenizing and add Phase D to batch. Homogenize for 5 minutes, until uniform. Switch to propeller mixer. Cool batch to 40-45° C. and add Phase E. Mix until uniform. Continue mixing and cool batch to room temperature (20-25° C.).

[0058] It is understood that the embodiments described herein are merely exemplary and that a person skilled in the art may make many variations and modifications without departing from the spirit and scope of the invention. All such variations and modifications are intended to be included within the scope of the invention. 

What is claimed is:
 1. Compounds of the following structural formula:

wherein R₁ is derived from a polypropoxylated fatty alcohol and has the structural formula:

wherein R₅ is a saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic moiety containing from 4 to 24 carbon atoms, and x is an integer from 3 to 30; and wherein R is derived from an aliphatic or aromatic monocarboxylic acid and has the structural formula: a)

wherein R₂, R₃ and R₄ are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl; or b)

wherein R₆ is H or OH or NH₂ or methyl or ethyl.
 2. The compond of claim 1, wherein R has the structural formula: a)

wherein R₂, R₃ and R₄ are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl.
 3. The compound of claim 1, wherein wherein R has the structural formula:

wherein R₆ is H or OH or NH₂ or methyl or ethyl.
 4. The compound of claim 1, wherein R₅ has from 7 to 24 carbon atoms.
 5. The compound PPG-3 Myristyl Ether Neoheptanoate.
 6. The compound PPG-4 Butyloctyl Ether Ethylhexanoate.
 7. The compound of claim 1, wherein R₅ is derived from a saturated or unsaturated, substituted or unsubstituted aliphatic fatty acid that contains from 2 to 24 carbon atoms.
 8. The compound of claim 1, wherein R₅ is derived from a saturated or unsaturated, substituted or unsubstituted aliphatic fatty acid that contains from 4 to 18 carbon atoms.
 9. The compound of claim 1, wherein R₅ is derived from an aliphatic fatty acid selected from the group consisting of 2-Ethyl Hexanoic acid, Caproic acid, Neopentanoic acid, Isostearic acid, Neoheptanoic acid and Oleic acid.
 10. The compond of claim 1, wherein X is 3 to
 10. 11. The compound of claim 1, wherein R₅ is derived from an aromatic monocarboxylic acid that contains from 7 to 9 carbon atoms.
 12. The compound of claim 1, wherein R₅ is derived from an aromatic monocarboxylic acid selected from the group consisting of Benzoic acid and p-Aminobenzoic acid.
 13. The compound of claim 1, wherein the aliphatic acid is Neoheptanoic acid.
 14. The compound of claim 1, wherein the aliphatic acid is 2-Ethylhexanoic acid.
 15. The compound of claim 1, wherein the fatty alcohol is Myristyl alcohol.
 16. The compound of claim 1, wherein the fatty alcohol is butyloctanol.
 17. A topical composition for topical application comprising: an effective amount of an active ingredient dispersed in the topical composition, the active ingredient selected from the group consisting of pigments, micronized physical sunscreens, organic sunscreens, self-tanning agents, opacifying agents, antiseptic agents, moisturizers, film formers, deodorant actives, emulsifiers, thickening agents and conditioning agents; and a dispersant emollient agent in sufficient amount to disperse such active ingredient, such agent being a compound of the following structural formula:

wherein R₁ is derived from a polypropoxylated fatty alcohol and has the structural formula:

wherein R₅ is a saturated or unsaturated, substituted or unsubstituted aliphatic or aromatic moiety containing from 4 to 24 carbon atoms, and x is an integer from 3 to 30; and wherein R is derived from an aliphatic or aromatic monocarboxylic acid and has the structural formula: a)

wherein R₂, R₃ and R₄ are independently selected from the group consisting of methyl, ethyl, propyl or isopropyl; or b)

wherein R₆ is H or OH or NH₂ or methyl or ethyl.
 18. The composition of claim 17, wherein the agent is PPG-3 Myristyl Ether Neoheptanoate.
 19. The composition of claim 17, wherein the agent PPG-4 Butyloctyl Ether Ethylhexanoate.
 20. The composition of claim 17, wherein the active ingredient is a pigment selected from the group consisting of Zinc Oxide or Titanium Dioxide.
 21. The composition of claim 20, wherein the pigment is present in an amount in the range of about 0.20 to about 40.0 percent by weight of said composition.
 22. The composition of claim 17, wherein at least one active ingredient is present in an amount in the range of about 0.20 to about 40.0 percent by weight of said composition.
 23. The composition of claim 17, wherein at least one active ingredient is present in an amount in the range of about 2.0 to about 20.0 percent by weight of said composition.
 24. The composition of claim 17, wherein the dispersant emollient agent is present in the range of about 0.2 to about 40.0 percent by weight of the composition.
 25. An oil phase dispersion comprising pigments or micronized metallic oxides dispersed in an oil with a dispersant agent which is a compound of claim
 1. 26. An oil phase dispersion comprising pigments or micronized metallic oxides dispersed in an oil with a dispersant agent which is PPG-3 Myristyl Ether Neoheptanoate.
 27. An oil phase dispersion comprising pigments or micronized metallic oxides dispersed in an oil with a dispersant agent which is PPG-4 Butyloctyl Ether Ethylhexanoate.
 28. A topical sunscreen composition comprising: an effective sunscreen amount of micronized titanium dioxide or zinc oxide; and a dispersant emollient agent in sufficient amount to disperse such active ingredient, such agent being a compound of claim
 1. 